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Description for Protein B4GALT3

UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3
3 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. This gene encodes an enzyme that may be mainly involved in the synthesis of the first N-acetyllactosamine unit of poly-N-acetyllactosamine chains. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.4.1.-; 2.4.1.38; 2.4.1.90
    KEGG - Orthology:
    K07968
    KEGG - Pathway(s):
    hsa00510; hsa00533; hsa00601; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 3; Beta-1,4-GalTase 3; Beta4Gal-T3; b4Gal-T3; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
    Approved Symbol:
    B4GALT3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • N-Acetyl-D-glucosamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04929 Entrez Gene ID: 8703 OMIM ID: 604014 Swissprot Accession: O60512;