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Description for Protein SLC4A4

solute carrier family 4, sodium bicarbonate cotransporter, member 4
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13575
    KEGG - Pathway(s):
    hsa04964
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Sodium bicarbonate cotransporter NBC1; Solute carrier family 4, sodium bicarbonate cotransporter, member 5; SLC4A5; Sodium bicarbonate cotransporter, kidney; kNBC; Sodium bicarbonate cotransporter, pancreas; pNBC; Sodium bicarbonate cotransporter, heart; hhNBC; Solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 1; Solute carrier family 4, sodium bicarbonate cotransporter, member 4 isoform 2
    Approved Symbol:
    SLC4A4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 26
    Human (de-) phosphorylation sites: 26; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Renal tubular acidosis, proximal, with ocular abnormalities(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 9
  • Isoform 2 : 9
  • Isoform 1 : 9
    • Additional Identifiers:

    HPRD: 04516 Entrez Gene ID: 8671 OMIM ID: 603345 Swissprot Accession: Q9Y6R1; A5JJ20;