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Description for Protein CBL

Cas-Br-M (murine) ecotropic retroviral transforming sequence
107 total interacting proteins; 69 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
  • UBA: Ubiquitin associated domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K04707
    KEGG - Pathway(s):
    hsa04012; hsa04120; hsa04144; hsa04630; hsa04660; hsa04910; hsa05100; hsa05200; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Proto-oncogene c-CBL; Signal transduction protein CBL
    Approved Symbol:
    CBL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01320 Entrez Gene ID: 867 OMIM ID: 165360 Swissprot Accession: P22681;