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Description for Protein EIF3D

eukaryotic translation initiation factor 3, subunit D
11 total interacting proteins; 8 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(phosphoproteome: 1; platelet: 3; undefined: 1)
Summary:
Eukaryotic translation initiation factor-3 (eIF3), the largest of the eIFs, is a multiprotein complex composed of at least ten nonidentical subunits. The complex binds to the 40S ribosome and helps maintain the 40S and 60S ribosomal subunits in a dissociated state. It is also thought to play a role in the formation of the 40S initiation complex by interacting with the ternary complex of eIF2/GTP/methionyl-tRNA, and by promoting mRNA binding. The protein encoded by this gene is the major RNA binding subunit of the eIF3 complex. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K03251
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Eukaryotic translation initiation factor 3, subunit 7; Eukaryotic translation initiation factor 3, subunit 7 zeta, 66/67KD; elF3-p66; elF3-Zeta; elF3d
Approved Symbol:
EIF3D
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 13
Human (de-) phosphorylation sites: 13; Platelet phosphorylation sites: 2
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04888 Entrez Gene ID: 8664 OMIM ID: 603915 Swissprot Accession: O15371;