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Description for Protein IRS2

insulin receptor substrate 2
41 total interacting proteins; 31 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/2)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PTBI: Phosphotyrosine-binding domain (IRS1-like)
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07187
    KEGG - Pathway(s):
    hsa04722; hsa04910; hsa04920; hsa04930; hsa04960
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Insulin receptor substrate 2
    Approved Symbol:
    IRS2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 84
    Human (de-) phosphorylation sites: 84; Platelet phosphorylation sites: 5
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Diabetes, type II, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02878 Entrez Gene ID: 8660 OMIM ID: 600797 Swissprot Accession: Q9Y4H2; Q9P084;