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Description for Protein DYNLL1

dynein, light chain, LC8-type 1
82 total interacting proteins; 39 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; microparticles: 1; platelet: 1)
Summary:
Cytoplasmic dyneins are large enzyme complexes with a molecular mass of about 1,200 kD. They contain two force-producing heads formed primarily from dynein heavy chains, and stalks linking the heads to a basal domain, which contains a varying number of accessory intermediate chains. The complex is involved in intracellular transport and motility. The protein described in this record is a light chain and exists as part of this complex but also physically interacts with and inhibits the activity of neuronal nitric oxide synthase. Binding of this protein destabilizes the neuronal nitric oxide synthase dimer, a conformation necessary for activity, and it may regulate numerous biologic processes through its effects on nitric oxide synthase activity. Alternate transcriptional splice variants have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K10418
KEGG - Pathway(s):
hsa04962
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Dynein cytoplasmic light chain 1; 8 kDa dynein light chain; Cytoplasmic dynein light polypeptide; DLC1; PIN; LC8; DLC8; HDLC1; DNCLC1; Dynein light chain LC8 type 1; LC8a; Protein inhibitor of neuronal nitric oxide synthase; Protein inhibitor of neuronal NOS; DNCL1; MGC126137; MGC126138
Approved Symbol:
DYNLL1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03334 Entrez Gene ID: 8655 OMIM ID: 601562 Swissprot Accession: P63167; Q6FGH9;