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Description for Protein PDE5A

phosphodiesterase 5A, cGMP-specific
3 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(cAMP/cGMP binding: 1; membrane: 1; microparticles: 1; platelet: 9; secretome: 1; undefined: 1)
Summary:
This gene encodes a cGMP-binding, cGMP-specific phosphodiesterase, a member of the cyclic nucleotide phosphodiesterase family. This phosphodiesterase specifically hydrolyzes cGMP to 5'-GMP. It is involved in the regulation of intracellular concentrations of cyclic nucleotides and is important for smooth muscle relaxation in the cardiovascular system. Alternative splicing of this gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • GAF: Domain present in phytochromes and cGMP-specific phosphodiesterases.
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.35
    KEGG - Orthology:
    K13762
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PDE5A1; Phosphodiesterase 5A, cGMP-specific; cGMP-specific 3`,5`-cyclic phosphodiesterase; CGB-PDE; cGMP-binding cGMP-specific phosphodiesterase; PDE5; CN5A; Phosphodiesterase 5A isoform 2; Phosphodiesterase 5A isoform 3; Phosphodiesterase 5A isoform 1
    Approved Symbol:
    PDE5A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 3-ISOBUTYL-1-METHYLXANTHINE(db);
  • 5-ethoxy-4-(1-methyl-7-oxo-3-propyl-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)thiophene-2-sulfonamide(db);
  • Citric Acid(db);
  • Dipyridamole(db);
  • Gamma-Glutamyl[S-(2-Iodobenzyl)Cysteinyl]Glycine(db);
  • Guanosine-5'-Monophosphate(db);
  • Pentoxifylline(db);
  • Sildenafil(db);
  • Tadalafil(db);
  • Theophylline(db);
  • Udenafil(db);
  • Vardenafil(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04497 Entrez Gene ID: 8654 OMIM ID: 603310 Swissprot Accession: O76074;