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Description for Protein DDX3Y

DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 5)
Summary:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, and it has a homolog on the X chromosome. The gene mutation causes male infertility, Sertoli cell-only syndrome or severe hypospermatogenesis, suggesting that this gene plays a key role in the spermatogenic process. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K11594
    KEGG - Pathway(s):
    hsa04622
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DEAD/H box 3, Y linked; DBY; DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; DEAD-box protein 3, Y-chromosomal
    Approved Symbol:
    DDX3Y
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 11
    Human (de-) phosphorylation sites: 11; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02452 Entrez Gene ID: 8653 OMIM ID: 400010 Swissprot Accession: O15523;