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Description for Protein NUMB

numb homolog (Drosophila)
25 total interacting proteins; 17 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 3)
Summary:
The protein encoded by this gene plays a role in the determination of cell fates during development. The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that has been shown to associate with EPS15, LNX1, and NOTCH1. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PTB: Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06057
    KEGG - Pathway(s):
    hsa04330
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    S171; Protein numb homolog; h-Numb; Numb homolog isoform 3; Numb homolog isoform 1; Numb homolog isoform 2; Numb homolog isoform 4
    Approved Symbol:
    NUMB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04767 Entrez Gene ID: 8650 OMIM ID: 603728 Swissprot Accession: P49757;