Summary:
The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
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| Domains and Motifs:
PAS: PAS domain
HLH: helix loop helix domain
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Gene Ontology:
KEGG - Enzyme ID(s):
KEGG - Orthology:
K09101
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KEGG - Pathway(s):
None Available
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Nomenclature / Alternative Names:
Nuclear receptor coactivator 1; Nuclear receptor coactivator 1 isoform 1; Nuclear receptor coactivator 1 isoform 3; SRC1; RIP160; F-SRC-1; MGC129719; MGC129720; Hin-2 protein; PAX3/NCOA1 fusion protein; EC 2.3.1.48; nuclear receptor coactivator 1 isoform 2
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Approved Symbol:
| (De-) Phosphorylations:
Phosphorylation Targets:
| Total phosphorylation targets: 0 |
| Human phosphorylation targets: 0; | Predicted platelet targets: 0 |
| Protein Characteristics:
|  Associated Drugs (DrugBank Accession):
(11-BETA)-11,21-DIHYDROXY-PREGN-4-ENE-3,20-DIONE(db);
(1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol(db);
(2S)-2-methoxy-3-{4-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-1-benzothiophen-7-yl}propanoic acid(db);
(2S)-3-(1-{[2-(2-CHLOROPHENYL)-5-METHYL-1,3-OXAZOL-4-YL]METHYL}-1H-INDOL-5-YL)-2-ETHOXYPROPANOIC ACID(db);
(5BETA)-PREGNANE-3,20-DIONE(db);
(8alpha,10alpha,13alpha,17beta)-17-[(4-hydroxyphenyl)carbonyl]androsta-3,5-diene-3-carboxylic acid(db);
1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z)(db);
1-CHLORO-6-(4-HYDROXYPHENYL)-2-NAPHTHOL(db);
2-(3-FLUORO-4-HYDROXYPHENYL)-7-VINYL-1,3-BENZOXAZOL-5-OL(db);
2-(5-HYDROXY-NAPHTHALEN-1-YL)-1,3-BENZOOXAZOL-6-OL(db);
2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID(db);
3-(3-FLUORO-4-HYDROXYPHENYL)-7-HYDROXY-1-NAPHTHONITRILE(db);
3-(6-HYDROXY-NAPHTHALEN-2-YL)-BENZO[D]ISOOXAZOL-6-OL(db);
3-BROMO-6-HYDROXY-2-(4-HYDROXYPHENYL)-1H-INDEN-1-ONE(db);
3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid(db);
4-(4-HYDROXYPHENYL)-1-NAPHTHALDEHYDE OXIME(db);
5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-CARBONITRILE(db);
Genistein(db);
MYRISTIC ACID(db);
N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE(db);
[5-HYDROXY-2-(4-HYDROXYPHENYL)-1-BENZOFURAN-7-YL]ACETONITRILE(db)
Associated Genetic Diseases:
None Available
| Predicted Transmembrane Domains:
Isoform 3 : 0
Isoform 2 : 0
Isoform 1 : 0
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| Additional Identifiers:
| HPRD: | 04070 | | Entrez Gene ID: | 8648 | | OMIM ID: | 602691 | | Swissprot Accession: | Q15788; | | |
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