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Description for Protein ABCB11

ATP-binding cassette, sub-family B (MDR/TAP), member 11
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05664
    KEGG - Pathway(s):
    hsa02010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Bile salt export pump; BSEP; Sister of P-Glycoprotein; SPGP
    Approved Symbol:
    ABCB11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine triphosphate(db);
  • Glibenclamide(db)

    Associated Genetic Diseases:

  • Cholestasis, benign recurrent intrahepatic 2(Pd);
  • Cholestasis, progressive familial intrahepatic 2(Pd)
    		• Predicted Transmembrane Domains:
    04436_1(10)
    Additional Identifiers:

    HPRD: 04436 Entrez Gene ID: 8647 OMIM ID: 603201 Swissprot Accession: O95342;