Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein PTCH2

patched 2
4 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a transmembrane receptor of the patched gene family. The encoded protein may function as a tumor suppressor in the hedgehog signaling pathway. Alterations in this gene have been associated with nevoid basal cell carcinoma syndrome, basal cell carcinoma, medulloblastoma, and susceptibility to congenital macrostomia. Alternatively spliced transcript variants have been described. (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11101
    KEGG - Pathway(s):
    hsa04340; hsa05200; hsa05217
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Patched protein homolog 2; PTC2; RP11-269F19.8
    Approved Symbol:
    PTCH2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Basal cell carcinoma(Pd);
  • Medulloblastoma(Pd)
    		• Predicted Transmembrane Domains:
    04722_1(11)
    Additional Identifiers:

    HPRD: 04722 Entrez Gene ID: 8643 OMIM ID: 603673 Swissprot Accession: Q9Y6C5;