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Description for Protein RUNX3

runt-related transcription factor 3
18 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K09279
KEGG - Pathway(s):
None Available
Nomenclature / Alternative Names:
Polyomavirus enhancer binding protein 2 alpha C subunit; Core binding factor, runt domain, alpha subunit 3; SL3/AKV core binding factor alpha C subunit; SL3 3 enhancer factor 1 alpha C subunit; Acute myeloid leukemia 2 protein; Oncogene AML 2; PEBP2 alpha C; PEA2 alpha C; AML2 GENE; CBF alpha 3; PEBP2AC; CBFA3; AML2; Runt-related transcription factor 3, isoform 1; Encoded by distal 5 prime portion of the mRNA; Runt-related transcription factor 3 isoform 1; Runt-related transcription factor 3 isoform 2
Approved Symbol:
RUNX3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 16
Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02565 Entrez Gene ID: 864 OMIM ID: 600210 Swissprot Accession: Q13761; B1AJV5;