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Description for Protein AOC3

amine oxidase, copper containing 3 (vascular adhesion protein 1)
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes in the presence of copper and quinone cofactor. The product is a major protein on the adipocyte plasma membrane. It has adhesive properties and also has functional monoamine oxidase activity. A pseudogene for this gene has been discribed and is located approximately 9-kb downstream. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.4.3.21
    KEGG - Orthology:
    K00276
    KEGG - Pathway(s):
    hsa00260; hsa00350; hsa00360; hsa00410; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    AOC3 Human placenta amine oxidase; HPAO; Vascular adhesion protein 1; VAP1; DAO; Diamine oxidase; Diamino oxhydrase; Histaminase; EC 1.4.3.6; Amine oxidase; Copper containing 3; Copper amine oxidase
    Approved Symbol:
    AOC3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,6-DICHLORO-N-IMIDAZOLIDIN-2-YLIDENEANILINE(db);
  • 6-hydroxydopa quinone(db);
  • Hydralazine(db);
  • Phenelzine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04770 Entrez Gene ID: 8639 OMIM ID: 603735 Swissprot Accession: Q16853;