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Description for Protein PDE8B

phosphodiesterase 8B
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • PAS: PAS domain
  • HDc: Metal dependent phosphohydrolases with conserved 'HD' motif.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.17
    KEGG - Orthology:
    K01120
    KEGG - Pathway(s):
    hsa00230
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    HSPDE8B; FLJ11212; 3 prime, 5 prime cyclic nucleotide phosphodiesterase 8B; High-affinity cAMP-specific and IBMX-insensitive 3 prime, 5 prime-cyclic phosphodiesterase 8B; EC 3.1.4.17; Phosphodiesterase 8B isoform 1; Phosphodiesterase 8B isoform 4; Phosphodiesterase 8B isoform 2; Phosphodiesterase 8B isoform 5; Phosphodiesterase 8B isoform 3
    Approved Symbol:
    PDE8B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 16
    Human (de-) phosphorylation sites: 16; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Ketotifen(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04546 Entrez Gene ID: 8622 OMIM ID: 603390 Swissprot Accession: O95263; Q3ZCW6; B3KMJ9;