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Description for Protein RUNX1T1

runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
38 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TAFH: TAF homology
  • NLS: Nuclear localization signal
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K10053
    KEGG - Pathway(s):
    hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acute myelogenous leukemia 1 translocation 1 protein isoform MTG8a; Acute myelogenous leukemia 1 translocation 1 protein isoform MTG8c; Acute myelogenous leukemia 1 translocation 1 protein isoform MTG8b; MTG8; AML1T1; ZMYND2; ETO gene; ETO protein; MTG8 protein; Protein CBFA2T1; Eigth twenty one protein; Cyclin D related protein; Myeloid translocation gene 8q22; Zinc finger MYND domain containing protein 2; Core binding factor alpha subunit 2 translocated to, 1; Acute myelogenous leukemia 1 translocation 1, cyclin D related; CBFA2T1; CDR; Hypothetical protein MGC2796; MTG8b; Acute myelogenous leukemia 1 translocation 1 protein
    Approved Symbol:
    RUNX1T1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 18
    Human (de-) phosphorylation sites: 18; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00590 Entrez Gene ID: 862 OMIM ID: 133435 Swissprot Accession: Q06455; Q7Z4J5;