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Description for Protein PPAP2B

phosphatidic acid phosphatase type 2B
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is a membrane glycoprotein localized at the cell plasma membrane. It has been shown to actively hydrolyze extracellular lysophosphatidic acid and short-chain phosphatidic acid. The expression of this gene is found to be enhanced by epidermal growth factor in Hela cells. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.4
    KEGG - Orthology:
    K01080
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa00565; hsa00600; hsa01100; hsa04666
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    VCIP; Dri42; PAP 2b; PAP2 b; MGC15306; Lipid phosphate phosphohydrolase 3; LPP3; PAP2-beta; Phosphatidic acid phosphohydrolase 2b; Type-2 phosphatidic acid phosphatase-beta; Vascular endothelial growth factor and type I collagen inducible; EC 3.1.3.4
    Approved Symbol:
    PPAP2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 06179 Entrez Gene ID: 8613 OMIM ID: 607125 Swissprot Accession: O14495;