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Description for Protein PPAP2C

phosphatidic acid phosphatase type 2C
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is similar to phosphatidic acid phosphatase type 2A (PPAP2A) and type 2B (PPAP2B). All three proteins contain 6 transmembrane regions, and a consensus N-glycosylation site. This protein has been shown to possess membrane associated PAP activity. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
  • AcidPPc: Acid phosphatase homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.4
    KEGG - Orthology:
    K01080
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa00565; hsa00600; hsa01100; hsa04666
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAP2C; Phosphatidic acid phosphohydrolase type 2c; PAP2-gamma; Lipid phosphate phosphohydrolase 2; Phosphatidic acid phosphatase 2c; Phosphatidate phosphohydrolase type 2c; LPP2; EC 3.1.3.4; PAP2g; Type 2 phosphatidic acid phosphatase-gamma; Phosphatidic acid phosphatase type 2C isoform 1; Phosphatidic acid phosphatase type 2C isoform 2; Phosphatidic acid phosphatase type 2C isoform 3
    Approved Symbol:
    PPAP2C
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 15
    Human (de-) phosphorylation sites: 15; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 5
  • Isoform 2 : 5
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 06180 Entrez Gene ID: 8612 OMIM ID: 607126 Swissprot Accession: O43688;