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Description for Protein PPAP2A

phosphatidic acid phosphatase type 2A
1 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the phosphatidic acid phosphatase (PAP) family. PAPs convert phosphatidic acid to diacylglycerol, and function in de novo synthesis of glycerolipids as well as in receptor-activated signal transduction mediated by phospholipase D. This protein is an integral membrane glycoprotein, and has been shown to be a surface enzyme that plays an active role in the hydrolysis and uptake of lipids from extracellular space. The expression of this gene is found to be regulated by androgen in a prostatic adenocarcinoma cell line. At least two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AcidPPc: Acid phosphatase homologues
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.3.4
    KEGG - Orthology:
    K01080
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa00565; hsa00600; hsa01100; hsa04666
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    PAP2; LPP1; LLP1a; PAP-2a; PAP2a2; PAPalpha1; PAP2alpha2; Phosphatidic acid phosphatase 2a; Lipid phosphate phosphohydrolase 1; Lipid phosphate phosphohydrolase 1a; Type 2 phosphatidic acid phosphohydrolase; Phosphatidic acid phosphohydrolase type 2a; Type-2 phosphatidic acid phosphatase alpha; Phosphatidic acid phosphatase type 2A isoform 2; Phosphatidic acid phosphatase type 2A isoform 1
    Approved Symbol:
    PPAP2A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 5
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 06178 Entrez Gene ID: 8611 OMIM ID: 607124 Swissprot Accession: O14494;