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Description for Protein RUNX1

runt-related transcription factor 1
45 total interacting proteins; 13 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K08367
KEGG - Pathway(s):
hsa05200; hsa05220; hsa05221
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Runt-related transcription factor 1 isoform b; Runt-related transcription factor 1 isoform a; Runt related transcription factor 1; PEBP2 alpha B; Core binding factor alpha 2 subunit; CBF alpha 2; Acute myeloid leukemia 1 protein; Oncogene AML-1; Polyomavirus enhancer binding protein 2 alpha B subunit; AML1; PEA2 alpha B; SL3-3 enhancer factor 1 alpha B subunit; AML1c
Approved Symbol:
RUNX1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 34
Human (de-) phosphorylation sites: 34; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Platelet disorder, familial, with associated myeloid malignancy(Pd);
  • Rheumatoid arthritis, susceptibility to(Pd);
  • Transient myeloproliferative disorder of down syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01043 Entrez Gene ID: 861 OMIM ID: 151385 Swissprot Accession: Q01196;