Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CAV3

caveolin 3
13 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alternative splicing has been identified for this locus, with inclusion or exclusion of a differentially spliced intron. In addition, transcripts utilize multiple polyA sites and contain two potential translation initiation sites. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12959
    KEGG - Pathway(s):
    hsa04144; hsa04510; hsa05100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    M caveolin; VIP21; LGMD1C; VIP-21; MGC126100; MGC126101; MGC126129; Caveolin-3
    Approved Symbol:
    CAV3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cardiomyopathy, familial hypertrophic(Pd);
  • Creatine phosphokinase, elevated serum(Pd);
  • Muscular dystrophy, limb-girdle, type 1C(Pd);
  • Muscular dystrophy, limb-girdle, type 1C, autosomal recessive(Pd);
  • Myopathy, distal, with decreased caveolin 3(Pd);
  • Rippling muscle disease 2(Pd);
  • Rippling muscle disease 2, autosomal recessive(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 03154 Entrez Gene ID: 859 OMIM ID: 601253 Swissprot Accession: A8K777; P56539;