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Description for Protein SCARF1

scavenger receptor class F, member 1
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/1)
(membrane: 1; phosphoproteome: 1; platelet: 2; undefined: 1)
Summary:
The protein encoded by this gene is a scavenger receptor that is expressed in endothelial cells and mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Transcription factors ZNF444/EZF-2 and SP1 are found to be responsible for the regulation of this gene. Five alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFL: EGF domain, unclasssified subfamily
  • TM: Transmembrane domain
  • EGF: Epidermal growth factor-like domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Scavenger receptor class F, member 1; Scavenger receptor expressed by endothelial cells; SREC; KIAA0149; Endothelial cells scavenger receptor; MGC47738; Acetyl LDL receptor; Scavenger receptor class F, member 1 isoform 1; Scavenger receptor class F, member 1 isoform 5; Scavenger receptor class F, member 1 isoform 3; Scavenger receptor class F, member 1 isoform 2; Scavenger receptor class F, member 1 isoform 4
    Approved Symbol:
    SCARF1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06386 Entrez Gene ID: 8578 OMIM ID: 607873 Swissprot Accession: Q14162; Q8NHD4; A8MQ05;