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Description for Protein MADD

MAP-kinase activating death domain
9 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NLS: Nuclear localization signal
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    MAP kinase activating death domain; Insulinoma glucagonoma protein 20; DENN; KIAA0358; MAP-kinase activating death domain-containing protein isoform e; MAP-kinase activating death domain-containing protein isoform f; MAP-kinase activating death domain-containing; protein isoform c; MAP-kinase activating death domain-containing protein isoform b; MAP-kinase activating death domain-containing protein isoform g; MAP-kinase activating death domain-containing protein isoform a; MAP-kinase activating death domain-containing protein isoform d; IG20
    Approved Symbol:
    MADD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 73
    Human (de-) phosphorylation sites: 73; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
    04664_10(0)
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04664 Entrez Gene ID: 8567 OMIM ID: 603584 Swissprot Accession: Q8WXG6; A8K8S7; B5MEE5;