Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein YARS

tyrosyl-tRNA synthetase
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(microparticles: 1; platelet: 3; undefined: 1)
Summary:
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
6.1.1.1
KEGG - Orthology:
K01866
KEGG - Pathway(s):
hsa00970
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
TYRRS; YRS; YTS; TyrRS; Tyrosyl tRNA ligase
Approved Symbol:
YARS
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-(2,2,2-TRIFLUOROETHYL)-L-PHENYLALANINE(db);
  • Beta-(2-Naphthyl)-Alanine(db);
  • L-Tyrosine(db);
  • N6-ISOPENTENYL-ADENOSINE-5'-MONOPHOSPHATE(db);
  • PARA-(BENZOYL)-PHENYLALANINE(db);
  • Tyrosinal(db)

    Associated Genetic Diseases:

  • Charcot-Marie-tooth disease, dominant intermediate c(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 09153 Entrez Gene ID: 8565 OMIM ID: 603623 Swissprot Accession: P54577;