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Description for Protein DEGS1

degenerative spermatocyte homolog 1, lipid desaturase (Drosophila)
5 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the membrane fatty acid desaturase family which is responsible for inserting double bonds into specific positions in fatty acids. This protein contains three His-containing consensus motifs that are characteristic of a group of membrane fatty acid desaturases. It is predicted to be a multiple membrane-spanning protein localized to the endoplasmic reticulum. Overexpression of this gene inhibited biosynthesis of the EGF receptor, suggesting a possible role of a fatty acid desaturase in regulating biosynthetic processing of the EGF receptor. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.-.-
    KEGG - Orthology:
    K04712
    KEGG - Pathway(s):
    hsa00600; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MLD; DEGS; DES1; Des-1; MIG15; MGC5079; Dihydroceramide desaturase; Sphingolipid delta 4 desaturase; Migration inducing gene 15 protein; Membrane fatty acid lipid desaturase
    Approved Symbol:
    DEGS1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 6
  • Isoform 1 : 6
    • Additional Identifiers:

    HPRD: 13133 Entrez Gene ID: 8560 OMIM ID: - Swissprot Accession: O15121;