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Description for Protein AP3B1

adaptor-related protein complex 3, beta 1 subunit
12 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(phosphoproteome: 1; platelet: 1; undefined: 1)
Summary:
This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K12397
KEGG - Pathway(s):
hsa04142
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Adapter related protein complex 3 beta 1 subunit; AP3 complex beta3A subunit; Beta-3A-adaptin; ADTB3A
Approved Symbol:
AP3B1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 6
Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 1
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Hermansky-pudlak syndrome 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04551 Entrez Gene ID: 8546 OMIM ID: 603401 Swissprot Accession: O00203;