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Description for Protein COPS3

COP9 constitutive photomorphogenic homolog subunit 3 (Arabidopsis)
26 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(platelet: 5; undefined: 1)
Summary:
The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PINT: motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K12177
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    SGN3; COP9 constitutive photomorphogenic homolog subunit 3; JAB1 containing signalosome subunit 3; COP9 complex subunit 3; COP9 signalosome 3-CSN3
    Approved Symbol:
    COPS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07262 Entrez Gene ID: 8533 OMIM ID: 604665 Swissprot Accession: Q9UNS2;