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Description for Protein ABCC11

ATP-binding cassette, sub-family C (CFTR/MRP), member 11
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
  • AAA: ATPases associated with a variety of cellular activities
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05671
    KEGG - Pathway(s):
    hsa02010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    WW; EWWD; ATP-binding cassette sub-family C member 11 isoform b; Multi resistance protein 8; ATP binding cassette transporter MRP8; ATP binding cassette, subfamily C, member 11; Multidrug resistance associated protein 8; MRP8; ATP-binding cassette, sub-family C member 11 isoform a; ATP-binding cassette, sub-family C, member 11 isoform a
    Approved Symbol:
    ABCC11
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Ear wax, wet/dry(Pd)
    		• Predicted Transmembrane Domains:
    06127_3(11)
    06127_2(11)
    06127_1(11)
    Additional Identifiers:

    HPRD: 06127 Entrez Gene ID: 85320 OMIM ID: 607040 Swissprot Accession: Q96J66;