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Description for Protein DGKD

diacylglycerol kinase, delta 130kDa
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SAM: Sterile alpha motif.
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PH: Pleckstrin homology domain.
  • DAGKC: Diacylglycerol kinase catalytic domain (presumed)
  • DAGKa: Diacylglycerol kinase accessory domain (presumed)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.107
    KEGG - Orthology:
    K00901
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Diacylglycerol kinase, delta 130kDa isoform 2; DGK isozyme, 135kd; DGK delta; Diglyceride kinase; DAG kinase delta; 135 kDa diacylglycerol kinase; Diacylglycerol kinase, delta 130kDa isoform 1
    Approved Symbol:
    DGKD
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 5
    Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphatidylserine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03492 Entrez Gene ID: 8527 OMIM ID: 601826 Swissprot Accession: Q16760;