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Description for Protein DGKZ

diacylglycerol kinase, zeta
20 total interacting proteins; 11 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It may attenuate protein kinase C activity by regulating diacylglycerol levels in intracellular signaling cascade and signal transduction. Alternative splicing occurs at this locus and multiple transcript variants encoding distinct isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ANK: ankyrin repeats
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • DAGKC: Diacylglycerol kinase catalytic domain (presumed)
  • DAGKa: Diacylglycerol kinase accessory domain (presumed)
  • ANX: Annexin repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.1.107
    KEGG - Orthology:
    K00901
    KEGG - Pathway(s):
    hsa00561; hsa00564; hsa01100; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    DGK zeta; Diglyceride kinase; DAG kinase zeta; Diacylglycerol kinase, zeta 104KD; DAGK5; DAGK6; hDGKzeta; EC 2.7.1.107; Diacylglycerol kinase, zeta 104kDa isoform 1; Diacylglycerol kinase, zeta 104kDa isoform 2; Diacylglycerol kinase, zeta 104kDa isoform 3
    Approved Symbol:
    DGKZ
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03260 Entrez Gene ID: 8525 OMIM ID: 601441 Swissprot Accession: Q13574; Q6ZVG7; A8MVN1;