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Description for Protein SEMA7A

semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene binds to cell surfaces through a glycosylphosphatidylinositol (GPI) linkage. The encoded glycoprotein is found on activated lymphocytes and erythrocytes. This protein may be involved in immunomodulatory and neuronal processes. Defects in this gene can result in loss of bone mineral density (BMD). Three transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • PSI: domain found in Plexins, Semaphorins and Integrins
  • IG: Immunoglobulin
  • SEMA: semaphorin domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06529
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    K1; SEMAL; CDw108; CD108; H-SEMA; H-Sema-L; H-Sema K1; Sema K1; Semaphorin L; Semaphorin K1; Cd108 Antigen; Jmh blood group antigen; John Milton Hargen human blood group antigen; John Milton Hargen human blood group Ag; Sema domain immunoglobulin domain GPI membrane anchor 7A
    Approved Symbol:
    SEMA7A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07081 Entrez Gene ID: 8482 OMIM ID: 607961 Swissprot Accession: O75326; B4DDP7;