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Description for Protein PLCD4

phospholipase C, delta 4
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Phosphatidylinositol-specific phospholipase C (PLC) plays an important role in receptor-mediated signal transduction by generating 2 second messenger molecules, inositol 1,4,5-triphosphate (IP3) and diacylglycerol, from phosphatidylinositol 4,5-bisphosphate (PIP2). PLC comprises a diverse family of enzymes that differ in structure and tissue distribution (Berridge, 1993 [PubMed 8381210]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • EF: EF-hand, calcium binding motif
  • PH: Pleckstrin homology domain.
  • C2: Protein kinase C conserved region 2 (CalB)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.4.11
    KEGG - Orthology:
    K05857
    KEGG - Pathway(s):
    hsa00562; hsa01100; hsa04020; hsa04070
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Phospholipase C delta 4
    Approved Symbol:
    PLCD4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 07296 Entrez Gene ID: 84812 OMIM ID: 605939 Swissprot Accession: Q9BRC7;