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Description for Protein CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like)
7 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CNH: Domain found in NIK1-like kinases, mouse citron and yeast ROM1, ROM2
  • PBD: P21-Rho-binding domain
  • CC: Coiled Coil
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • C1: Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)
  • PH: Pleckstrin homology domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.-
    KEGG - Orthology:
    K08286
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    PK428; Ser-thr protein kinase PK428; Myotonic dystrophy kinase-related CDC42-binding protein kinase alpha; MRCK; MRCKA; FLJ23347; KIAA0451; DKFZp686L1738; DKFZp686P1738; CDC42-binding protein kinase alpha, DMPK like; Ser-Thr protein kinase related to the myotonic dystrophy protein kinase; CDC42 binding protein kinase alpha isoform B; CDC42 binding protein kinase alpha isoform A; Protein kinase, serine/threonine, related to the myotonic dystrophy protein kinase; Serine/threonine-protein kinase MRCK alpha; EC 2.7.1.37; MRCK alpha; DMPK-like alpha
    Approved Symbol:
    CDC42BPA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 33
    Human (de-) phosphorylation sites: 33; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04562 Entrez Gene ID: 8476 OMIM ID: 603412 Swissprot Accession: Q5VT25;