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Description for Protein CBX2

chromobox homolog 2
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. (PubMed Links)
Domains and Motifs:
  • CHROMO: Chromatin organization modifier domain
  • AT_hook: DNA binding domain with preference for A/T rich regions
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K11451
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    CDCA6; M33; MGC10561; M33 polycomb-like; Cell division cycle associated 6; Modifier 3; Chromobox homolog 2; Chromobox homolog 2 isoform 1; Chromobox homolog 2 isoform 2
    Approved Symbol:
    CBX2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 14397 Entrez Gene ID: 84733 OMIM ID: 602770 Swissprot Accession: Q14781;