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Description for Protein FKBP6

FK506 binding protein 6, 36kDa
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The protein may have cis-trans prolyl isomerase activity, and binds to clathrin heavy chain and heat shock protein 72. This gene is found to be deleted in Williams syndrome, and the orthologous gene in mouse is essential for fertility and homologous pairing in male meiosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TPR: Tetratricopeptide repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    5.2.1.8
    KEGG - Orthology:
    K09572
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    FK506 binding protein 6, 36kDa; FKBP36; PPIase; Rotamase; Immunophilin; Peptidylprolyl cis-trans isomerase
    Approved Symbol:
    FKBP6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05326 Entrez Gene ID: 8468 OMIM ID: 604839 Swissprot Accession: O75344; B4DXT7;