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Description for Protein KDM2B

lysine (K)-specific demethylase 2B
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • F_BOX: A Receptor for Ubiquitination Targets
  • LRR: Leucine-rich repeats, outliers
  • JMJC: A domain family that is part of the cupin metalloenzyme superfamily.
  • PHD: PHD zinc finger
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.14.11.27
    KEGG - Orthology:
    K10276
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    F-box protein FBL10; JEMMA protein; CXXC finger protein 2; FBL10; PCCX2; CXXC2; Fbl10; Protein containing CXXC domain 2; JEMMA (Jumonji domain, EMSY-interactor, methyltransferase motif) protein; F-box and leucine-rich repeat protein 10 isoform a; F-box and leucine-rich repeat protein 10 isoform b
    Approved Symbol:
    KDM2B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 51
    Human (de-) phosphorylation sites: 51; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 12362 Entrez Gene ID: 84678 OMIM ID: 609078 Swissprot Accession: Q8NHM5; A8MRS1;