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Description for Protein CUL4B

cullin 4B
42 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 4)
Summary:
This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K10609
KEGG - Pathway(s):
hsa03420; hsa04120
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Cullin homolog 4B; KIAA0695; Cullin 4B isoform 2
Approved Symbol:
CUL4B
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 40
Human (de-) phosphorylation sites: 40; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Cabezas syndrome(Pd);
  • Mental retardation-hypotonic facies syndrome, X-linked, 2(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02251 Entrez Gene ID: 8450 OMIM ID: 300304 Swissprot Accession: Q13620;