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Description for Protein DYRK3

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.12.1
    KEGG - Orthology:
    K08825
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3; RED; REDK; Regulatory erythroid kinase; Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 isoform b; Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 isoform a
    Approved Symbol:
    DYRK3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04607 Entrez Gene ID: 8444 OMIM ID: 603497 Swissprot Accession: O43781;