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Description for Protein NCK2

NCK adaptor protein 2
36 total interacting proteins; 19 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(membrane: 1; microparticles: 1; phosphoproteome: 1; platelet: 6; secretome: 1; undefined: 1)
Summary:
This gene encodes a member of the NCK family of adaptor proteins. The protein contains three SH3 domains and one SH2 domain. The protein has no known catalytic function but has been shown to bind and recruit various proteins involved in the regulation of receptor protein tyrosine kinases. It is through these regulatory activities that this protein is believed to be involved in cytoskeletal reorganization. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • SH2: Src homology 2 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07365
    KEGG - Pathway(s):
    hsa04012; hsa04360; hsa04660; hsa05130
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Cytoplasmic protein NCK2; SH2/SH3 adaptor protein NCK beta; Noncatalytic region of tyrosine kinase beta; NCK beta; NCK adaptor protein 2; NCK adaptor protein 2 isoform A; NCK adaptor protein 2 isoform B
    Approved Symbol:
    NCK2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; Platelet phosphorylation sites: 2
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05378 Entrez Gene ID: 8440 OMIM ID: 604930 Swissprot Accession: O43639;