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Description for Protein RAD54L

RAD54-like (S. cerevisiae)
3 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein. (PubMed Links)
Domains and Motifs:
  • DEXDc: DEAD-like helicases superfamily
  • HELIC: helicase superfamily c-terminal domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.6.1.-
    KEGG - Orthology:
    K10875
    KEGG - Pathway(s):
    hsa03440
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RAD54; RAD54 homolog; HR54; HRAD54; hHR54; RAD54 -like; RAD54A
    Approved Symbol:
    RAD54L
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Adenocarcinoma, colonic(Pd);
  • Breast cancer, invasive ductal(Pd);
  • Lymphoma, non-Hodgkin(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04683 Entrez Gene ID: 8438 OMIM ID: 603615 Swissprot Accession: Q92698; A8K996;