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Description for Protein CASP10

caspase 10, apoptosis-related cysteine peptidase
34 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with apoptosis defects seen in type II autoimmune lymphoproliferative syndrome. Three alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DED: Death effector domain
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.63
    KEGG - Orthology:
    K04400
    KEGG - Pathway(s):
    hsa04210; hsa04622
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    FADD like ICE2; Apoptotic protease MCH4; ICE like apoptotic protease 4; Interleukin-1B-converting enzyme 2; Fas associated death domain protein; MCH4; ALPS2; FLICE2; Caspase 10 isoform a; Caspase 10 isoform b; Caspase 10 isoform d
    Approved Symbol:
    CASP10
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Autoimmune lymphoproliferative syndrome, type IIA(Pd);
  • Gastric cancer, somatic(Pd);
  • Non-Hodgkin lymphoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03458 Entrez Gene ID: 843 OMIM ID: 601762 Swissprot Accession: Q92851;