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Description for Protein CAMKK1

calcium/calmodulin-dependent protein kinase kinase 1, alpha
8 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.17
    KEGG - Orthology:
    K07359
    KEGG - Pathway(s):
    hsa04920
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    CAMKKA; EC 2.7.1.37; MGC34095; CaMKK alpha; DKFZp761M0423; CaM kinase IV kinase; CaM kinase kinase alpha; Calcium/calmodulin dependent protein kinase kinase 1 alpha; Calcium/calmodulin-dependent protein kinase 1 alpha isoform a; Calcium/calmodulin-dependent protein kinase 1 alpha isoform b
    Approved Symbol:
    CAMKK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 17
    Human (de-) phosphorylation sites: 17; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 6
    Human phosphorylation targets: 6; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 13000 Entrez Gene ID: 84254 OMIM ID: 611411 Swissprot Accession: Q8N5S9;