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Description for Protein LTBP4

latent transforming growth factor beta binding protein 4
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene binds transforming growth factor beta (TGFB) as it is secreted and targeted to the extracellular matrix. TGFB is biologically latent after secretion and insertion into the extracellular matrix, and sheds TGFB and other proteins upon activation. Defects in this gene may be a cause of cutis laxa and severe pulmonary, gastrointestinal, and urinary abnormalities. Three transcript variants encoding different isoforms have been found for this gene. (PubMed Links)
Domains and Motifs:
  • EGFCA: Calcium-binding EGF-like domain
  • EGF: Epidermal growth factor-like domain.
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08023
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Latent transforming growth factor beta binding protein 4, short; LTBP4S; Latent transforming growth factor beta binding protein 4, long; LTBP4L; Latent transforming growth factor beta binding protein 4 isoform a; Latent transforming growth factor beta binding protein 4 isoform c; Latent transforming growth factor beta binding protein 4 isoform b
    Approved Symbol:
    LTBP4
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 05274 Entrez Gene ID: 8425 OMIM ID: 604710 Swissprot Accession: Q8N2S1; B3KXY6;