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Description for Protein TRAF7

TNF receptor-associated factor 7
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • RING: Ring finger
  • CC: Coiled Coil
  • WD40: WD40 repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K10646
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    EC 6.3.2.-; RING finger protein 119; TNF receptor-associated factor 7; Ring finger and WD repeat domain 1 isoform 1; Ring finger and WD repeat containig domain 1; RNF119; RFWD1
    Approved Symbol:
    TRAF7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06977 Entrez Gene ID: 84231 OMIM ID: 606692 Swissprot Accession: Q6Q0C0; B3KQY7;