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Description for Protein CASP9

caspase 9, apoptosis-related cysteine peptidase
44 total interacting proteins; 20 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(undefined: 1)
Summary:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CARD: Caspase recruitment domain
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.62
    KEGG - Orthology:
    K04399
    KEGG - Pathway(s):
    hsa04115; hsa04210; hsa04370; hsa05010; hsa05012; hsa05014; hsa05016; hsa05200; hsa05210; hsa05212; hsa05213; hsa05215; hsa05222; hsa05223; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Caspase 9 isoform alpha preproprotein; Caspase 9 isoform beta preproprotein; ICE like apoptotic protease 6; Apoptotic protease activating factor 3; MCH6; APAF3; ICE-LAP6; CASPASE-9c; Caspase 9; OTTHUMP00000044594; Apoptotic protease MCH-6; ICE-like apoptotic protease 6; Caspase 9, apoptosis-related cysteine protease; EC 3.4.22.62; CASP-9
    Approved Symbol:
    CASP9
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 13
    Human (de-) phosphorylation sites: 13; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03756 Entrez Gene ID: 842 OMIM ID: 602234 Swissprot Accession: P55211;