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Description for Protein USP48

ubiquitin specific peptidase 48
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DUSP: Domain in ubiquitin-specific proteases.
  • CC: Coiled Coil
  • UCH: Ubiquitin carboxyl-terminal hydrolase
  • UBQ: Ubiquitin homologues
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.2.15
    KEGG - Orthology:
    K11858
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    DKFZp762M1713; USP31; RAP1GA1; MGC14879; Ubiquitin specific protease 31; FLJ23277; FLJ11328; FLJ20103; FLJ23054; Ubiquitin specific protease 48 isoform a; Ubiquitin specific protease 48 isoform b
    Approved Symbol:
    USP48
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 15637 Entrez Gene ID: 84196 OMIM ID: - Swissprot Accession: Q86UV5;