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Description for Protein POLR1B

polymerase (RNA) I polypeptide B, 128kDa
12 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • PHD: PHD zinc finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.7.6
    KEGG - Orthology:
    K03002
    KEGG - Pathway(s):
    hsa00230; hsa00240; hsa01100; hsa03020
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Rpo1-2; RPA135; FLJ21921; FLJ10816; RNA polymerase I subunit 2; DNA-directed RNA polymerase I 135kDa polypeptide
    Approved Symbol:
    POLR1B
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 06852 Entrez Gene ID: 84172 OMIM ID: 602000 Swissprot Accession: Q9H9Y6;