Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein CASP8

caspase 8, apoptosis-related cysteine peptidase
96 total interacting proteins; 48 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • DED: Death effector domain
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.61
    KEGG - Orthology:
    K04398
    KEGG - Pathway(s):
    hsa04115; hsa04210; hsa04620; hsa04621; hsa04622; hsa05010; hsa05016; hsa05142; hsa05200; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Caspase 8 isoform A; Mch5 isoform alpha; MACH alpha-1/2/3 protein; MACH beta-1/2/3/4 protein; FADD homologous ICE/CED-3-like protease; MACH; MCH5; FLICE; Caspase 8 isoform B; Caspase 8 isoform C; Caspase 8 isoform E; Caspase 8 isoform G precursor; Caspase 8 isoform C precursor
    Approved Symbol:
    CASP8
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 32
    Human (de-) phosphorylation sites: 32; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Caspase 8 deficiency(Pd);
  • Hepatocellular carcinoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03459 Entrez Gene ID: 841 OMIM ID: 601763 Swissprot Accession: Q14790;