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Description for Protein OBSCN

obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
5 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 5; secretome: 1)
Summary:
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • IGC2: Immunoglobulin C-2 Type
  • IG: Immunoglobulin
  • FN3: Fibronectin type 3 domain
  • IQ: Short calmodulin-binding motif containing conserved Ile and Gln residues.
  • SH3: Src homology 3 domains
  • RHOGEF: Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
  • CC: Coiled Coil
  • PH: Pleckstrin homology domain.
  • IGV: Immunoglobulin V-Type
  • Ig_LIKE: Immunoglobulin like
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
  • S_T_Y_Kinase: Protein kinase
  • unclassified specificity
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    UNC89; KIAA1556; Obscurin rho GEF; Obscurin MLCK; DKFZp666E245; MGC138590; MGC120412; MGC120411; MGC120410; MGC120409; KIAA1639; FLJ14124; Obscurin, myosin light chain kinase; EC 2.7.11.1; Obscurin
    Approved Symbol:
    OBSCN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 12
    Human (de-) phosphorylation sites: 12; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 10551 Entrez Gene ID: 84033 OMIM ID: 608616 Swissprot Accession: Q5VST9;