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Description for Protein CASP7

caspase 7, apoptosis-related cysteine peptidase
51 total interacting proteins; 24 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CASc: Caspase, interleukin-1 beta converting enzyme (ICE) homologues
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.4.22.60
    KEGG - Orthology:
    K04397
    KEGG - Pathway(s):
    hsa04210; hsa05010
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Caspase 7 isoform alpha; Caspase 7 isoform alpha precursor; Lice2 alpha/beta/gamma; Apoptotic protease MCH3; ICE like apoptotic protease 3; MCH3; CMH1; ICE-LAP3; Caspase 7, apoptosis-related cysteine peptidase; Caspase 7 isoform delta; Caspase 7 isoform beta
    Approved Symbol:
    CASP7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Dica(db);
  • Fica(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03457 Entrez Gene ID: 840 OMIM ID: 601761 Swissprot Accession: P55210;